{"id":9611,"date":"2023-03-10T10:19:43","date_gmt":"2023-03-10T10:19:43","guid":{"rendered":"https:\/\/demo.wockhardt.com\/?page_id=9611"},"modified":"2024-10-30T14:25:00","modified_gmt":"2024-10-30T14:25:00","slug":"wck-4282","status":"publish","type":"page","link":"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4282\/","title":{"rendered":"WCK 4282"},"content":{"rendered":"\t\t
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Towards optimizing cefepime\/tazobactam (WCK 4282) exposure to achieve efficacy against piperacillin\/tazobactam-resistant ESBL infections: dose recommendations for various renal functions, including intermittent haemodialysis, in healthy individuals<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Anouk E Muller, Brenda C M De Winter, Birgit C P Koch<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation – <\/strong>Volume 79, Issue 5, May 2024, Pages 1093\u20131100<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ensuring robustness in the quality of antibiotic susceptibility test discs for four novel antibiotics<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Vinod K. Ahirrao, Rajiv A. Jadhav, Suyog N. Vaidya, Sachin S. Bhagwat, Ravindra D. Yeole, Mahesh V. Patel<\/p>

Journal Name –\u00a0<\/strong>Biomedical Chromatography<\/p>

Citation – <\/strong>Volume 36, Issue 6, June 2022<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Hg (OAc) 2\/1, 2, 3-triazole-mediated efficient synthesis of Tazobactam<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Yasinalli Tamboli, Amit P Pund, Jaydeo T Kilbile, Arvind Y Merwade<\/p>\n

Journal Name – <\/strong>Chemical Papers<\/p>\n

Impact Factor – <\/strong>2.14<\/p>\n

Citation – <\/strong>AOP, 2022 <\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Antimicrobial Activity of High-Dose Cefepime-tazobactam (WCK 4282) against a Large Collection of Gram-negative Organisms Collected Worldwide in 2018 and 2019<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Helio S.Sader, Cecilia G.Carvalhaes, Rodrigo E.Mendes, Mariana Castanheira<\/p>

Journal Name –\u00a0<\/strong>International Journal of Infectious Diseases<\/p>

Impact Factor – <\/strong>1.278<\/p>

Citation – <\/strong>2022, 116, 306-312\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Cefepime\/tazobactam compared with other tazobactam combinations against problem Gram-negative bacteria<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Shazad Mushtaq, Paolo Garello, Anna Vickers, Neil Woodford, David M Livermore<\/p>

Journal Name –\u00a0<\/strong>International Journal of Antimicrobial Agents<\/p>

Impact Factor – <\/strong>4.621<\/p>

Citation – <\/strong>2021, 57(5), May, 106318\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vivo Activity of WCK 4282 (High-Dose Cefepime\/Tazobactam) against Serine-\u03b2-Lactamase-Producing Enterobacterales and Pseudomonas aeruginosa in the Neutropenic Murine Lung Infection Model<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Maxwell J. Lasko, Kamilia Abdelraouf, David P. Nicolau<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Impact Factor – <\/strong>4.904<\/p>

Citation – <\/strong>2021, 65(4), e02193-20\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vivo Activity of WCK 4282 (High-Dose Cefepime\/Tazobactam) against Serine-\u03b2-Lactamase-Producing Enterobacterales and Pseudomonas aeruginosa in the Neutropenic Murine thigh Infection Model<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Christian M Gill, Kamilia Abdelraouf, David P Nicolau<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Impact Factor – <\/strong>5.439<\/p>

Citation – <\/strong>2021, 76(4), 993-1000\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Single-Center Investigation of the Pharmacokinetics of WCK 4282 (Cefepime-Tazobactam Combination) in Renal Impairment<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Preston, Richard A.; Mamikonyan, Grigor; Mastim, Mushtaque; Garg, Dyal; Kemper, Christopher J.; Xu, Allan; Yeole, Ravindra; Chavan, Rajesh; Friedland, H. David; Bhatia, Ashima<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Impact Factor – <\/strong>4.921<\/p>

Citation – <\/strong>2019, 63(10), e00873-19\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Antimicrobial Susceptibility Testing Quality Control of \u03b2-lactam\/ \u03b2-lactamase Inhibitor Combination Agents in Clinical Development<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Ayuen Lual, Heena Shah, Jane E. Ambler, Suyog Vaidya, Brian Beck<\/p>

Journal Name –\u00a0<\/strong>CLSI AST News Update<\/p>

Citation – <\/strong>2019, 4(1), 20-21\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Potential of high-dose cefepime\/tazobactam against multiresistant Gram-negative pathogens<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> David M Livermore, Shazad Mushtaq, Marina Warner, Simon J Turner, Neil Woodford<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Impact Factor – <\/strong>5.113<\/p>

Citation – <\/strong>2018, 73(1), 126\u2013133\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Cefepime in an In Vitro Infection Model <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Brian D. VanScoy, David Tenero, Simon Turner, David M. Livermore, Jennifer McCauley, Haley Conde, Sujata M. Bhavnani, Christopher M. Rubino, Paul G. Ambrose<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Impact Factor – <\/strong>4.548<\/p>

Citation – <\/strong>2017, 61(12), e01052-17\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Determination of Disk Diffusion and MIC Quality Control Guidelines for High-Dose Cefepime-Tazobactam (WCK 4282), a Novel Antibacterial Combination Consisting of a \u03b2-Lactamase Inhibitor and a Fourth-Generation Cephalosporin<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Stefan Riedel, Michael D Huband, Helio S Sader, Robert K Flamm, Ronald N Jones<\/p>

Journal Name –\u00a0<\/strong>Journal of Clinical Microbiology<\/p>

Impact Factor – <\/strong>4.054<\/p>

Citation – <\/strong>2017, 55(10), 3130-3134\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Antimicrobial Activity of High-Proportion Cefepime-Tazobactam (WCK 4282) against a Large Number of Gram-Negative Isolates Collected Worldwide in 2014<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Sader, Helio S.; Castanheira, Mariana; Mendes, Rodrigo E.; Flamm, Robert K.; Jones, Ronald N<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Impact Factor – <\/strong>4.548<\/p>

Citation – <\/strong>2017, 61(4), e02409-16\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Enhanced activity of cefepime-tazobactam (WCK 4282) against KPC-producing Enterobacteriaceae when tested in media supplemented with human serum or sodium chloride<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Mariana Castanheira, Leonard R.Duncan, Paul R.Rhomberg, Helio S.Sader<\/p>

Journal Name –\u00a0<\/strong>Diagnostic Microbiology and Infectious Disease<\/p>

Impact Factor – <\/strong>2.341<\/p>

Citation – <\/strong>2017, 89(4), 305-309<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Pharmacodynamics of Cefepime Combined with Tazobactam against Clinically Relevant Enterobacteriaceae in a Neutropenic Mouse Thigh Model<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Maria J. Melchers, Anita C. van Mil, Claudia Lagarde, Jan den Hartigh, Johan W. Mouton<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Impact Factor – <\/strong>4.548<\/p>

Citation – <\/strong>2017, 61(9), e00267-17\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Towards optimizing cefepime\/tazobactam (WCK 4282) exposure to achieve efficacy against piperacillin\/tazobactam-resistant ESBL infections: dose recommendations for various renal functions, including intermittent haemodialysis, in healthy individuals Author – Anouk E Muller, Brenda C M De Winter, Birgit C P Koch Journal Name –\u00a0Journal of Antimicrobial Chemotherapy Citation – Volume 79, Issue 5, May 2024, Pages 1093\u20131100 … <\/p>\n

Continue reading “WCK 4282”<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":9547,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"yoast_head":"\nWCK 4282 - Wockhardt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4282\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"WCK 4282 - Wockhardt\" \/>\n<meta property=\"og:description\" content=\"Towards optimizing cefepime\/tazobactam (WCK 4282) exposure to achieve efficacy against piperacillin\/tazobactam-resistant ESBL infections: dose recommendations for various renal functions, including intermittent haemodialysis, in healthy individuals Author – Anouk E Muller, Brenda C M De Winter, Birgit C P Koch Journal Name –\u00a0Journal of Antimicrobial Chemotherapy Citation – Volume 79, Issue 5, May 2024, Pages 1093\u20131100 … Continue reading "WCK 4282"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4282\/\" \/>\n<meta property=\"og:site_name\" content=\"Wockhardt\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-30T14:25:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.wockhardt.com\/wp-content\/uploads\/2023\/05\/01_Journal_of_Antimicrobial_Chemotherapy.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4282\/\",\"url\":\"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4282\/\",\"name\":\"WCK 4282 - 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